Assay Detail
Functional
CHEMBL1826480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Hep3B2 cells after 72 hrs by MTS assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation and characterization of aphidicolin and chlamydosporol derivatives from Tolypocladium inflatum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.25 | 10.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 10.80 |
| CHEMBL1824861 | INFLATIN B | — | 1 | 5.14 |
| CHEMBL1824860 | INFLATIN A | — | 1 | 4.83 |
| CHEMBL1824865 | INFLATIN F | — | 1 | 4.24 |
| CHEMBL1824862 | INFLATIN C | — | 1 | - |
| CHEMBL1824863 | INFLATIN D | — | 1 | - |
| CHEMBL1824864 | INFLATIN E | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.016 | nM | 10.80 |
| CHEMBL1824861 | INFLATIN B | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1824860 | INFLATIN A | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1824865 | INFLATIN F | IC50 | = | 57500.0 | nM | 4.24 |
| CHEMBL1824862 | INFLATIN C | IC50 | > | 100000.0 | nM | - |
| CHEMBL1824863 | INFLATIN D | IC50 | > | 100000.0 | nM | - |
| CHEMBL1824864 | INFLATIN E | IC50 | > | 100000.0 | nM | - |