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Assay Detail

CHEMBL1826790

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Binding
Inhibition of human c-MET
ChEMBL ↗
449
Total Activities
448
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Hepatocyte growth factor receptor (CHEMBL3717) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met.
Xie QQ, Zhong L, Pan YL, Wang XY, Zhou JP, Di-Wu L, Huang Q, Wang YL, Yang LL, Xie HZ, Yang SY.
Eur J Med Chem (2011) 46 : 3675 -3680
PubMed 21641696 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 449 7.07 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1822369 — — 1 9.30
CHEMBL1822366 — — 1 9.15
CHEMBL1822368 — — 1 9.15
CHEMBL462622 — — 1 9.00
CHEMBL462624 — — 1 9.00
CHEMBL460465 — — 1 9.00
CHEMBL518174 — — 1 9.00
CHEMBL1822791 — — 2 9.00
CHEMBL497118 — — 1 9.00
CHEMBL460466 — — 1 9.00
CHEMBL494985 — — 1 9.00
CHEMBL1823128 — — 1 9.00
CHEMBL1823252 — — 1 9.00
CHEMBL460468 — — 1 8.96
CHEMBL461293 — — 1 8.89
CHEMBL459875 — — 1 8.89
CHEMBL254086 — — 1 8.82
CHEMBL1822371 — — 1 8.80
CHEMBL459876 — — 1 8.74
CHEMBL509101 — — 1 8.74
CHEMBL451809 — — 1 8.72
CHEMBL523386 — — 1 8.70
CHEMBL525260 — — 1 8.70
CHEMBL502531 — — 1 8.70
CHEMBL205372 — — 1 8.70
CHEMBL1822370 — — 1 8.70
CHEMBL1822792 MK-2461 2.0 1 8.70
CHEMBL524364 — — 1 8.70
CHEMBL503139 — — 1 8.64
CHEMBL1823478 — — 1 8.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1822369 — IC50 = 0.5 nM 9.30
CHEMBL1822368 — IC50 = 0.7 nM 9.15
CHEMBL1822366 — IC50 = 0.7 nM 9.15
CHEMBL1822791 — IC50 = 1.0 nM 9.00
CHEMBL497118 — IC50 = 1.0 nM 9.00
CHEMBL462622 — IC50 = 1.0 nM 9.00
CHEMBL462624 — IC50 = 1.0 nM 9.00
CHEMBL460465 — IC50 = 1.0 nM 9.00
CHEMBL518174 — IC50 = 1.0 nM 9.00
CHEMBL460466 — IC50 = 1.0 nM 9.00
CHEMBL494985 — IC50 = 1.0 nM 9.00
CHEMBL1823252 — IC50 = 1.0 nM 9.00
CHEMBL1823128 — IC50 = 1.0 nM 9.00
CHEMBL460468 — IC50 = 1.1 nM 8.96
CHEMBL459875 — IC50 = 1.3 nM 8.89
CHEMBL461293 — IC50 = 1.3 nM 8.89
CHEMBL254086 — IC50 = 1.5 nM 8.82
CHEMBL1822371 — IC50 = 1.6 nM 8.80
CHEMBL459876 — IC50 = 1.8 nM 8.74
CHEMBL509101 — IC50 = 1.8 nM 8.74
CHEMBL451809 — IC50 = 1.9 nM 8.72
CHEMBL524364 — IC50 = 2.0 nM 8.70
CHEMBL525260 — IC50 = 2.0 nM 8.70
CHEMBL502531 — IC50 = 2.0 nM 8.70
CHEMBL1822370 — IC50 = 2.0 nM 8.70
CHEMBL523386 — IC50 = 2.0 nM 8.70
CHEMBL1822792 MK-2461 IC50 = 2.0 nM 8.70
CHEMBL205372 — IC50 = 2.0 nM 8.70
CHEMBL503139 — IC50 = 2.3 nM 8.64
CHEMBL1823478 — IC50 = 2.5 nM 8.60
CHEMBL461583 — IC50 = 2.6 nM 8.59
CHEMBL445799 — IC50 = 2.7 nM 8.57
CHEMBL518656 — IC50 = 2.7 nM 8.57
CHEMBL454356 — IC50 = 2.8 nM 8.55
CHEMBL494984 — IC50 = 3.0 nM 8.52
CHEMBL567908 — IC50 = 3.0 nM 8.52
CHEMBL500157 — IC50 = 3.0 nM 8.52
CHEMBL454357 — IC50 = 3.1 nM 8.51
CHEMBL461582 — IC50 = 3.2 nM 8.49
CHEMBL455386 — IC50 = 3.4 nM 8.47
CHEMBL517293 — IC50 = 3.4 nM 8.47
CHEMBL462623 — IC50 = 3.4 nM 8.47
CHEMBL508633 — IC50 = 3.8 nM 8.42
CHEMBL460502 — IC50 = 3.8 nM 8.42
CHEMBL460702 BMS-777607 IC50 = 3.9 nM 8.41
CHEMBL499886 — IC50 = 4.0 nM 8.40
CHEMBL1822790 — IC50 = 4.0 nM 8.40
CHEMBL1822974 — IC50 = 4.0 nM 8.40
CHEMBL525049 — IC50 = 4.0 nM 8.40
CHEMBL494979 — IC50 = 4.0 nM 8.40