Compound Detail
CHEMBL205372
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Basic Information
| ChEMBL ID | CHEMBL205372 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BRXZUOJFGVQTAB-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
473.6
MW (Da)
5.10
ALogP
6
HBA
2
HBD
81.7
PSA (Ų)
0.36
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.7
Ki 1 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Hepatocyte growth factor receptor CHEMBL3717 | Ki | 8.7 | 8.7 | 2.0 | 1 |
| Platelet-derived growth factor receptor alpha CHEMBL2007 | IC50 | 7.55 | 7.55 | 28.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 6.7 | 6.7 | 202.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 2.0 | nM | 8.7 | Inhibition of human c-MET | 21641696 |
| Hepatocyte growth factor receptor | Ki | = | 2.0 | nM | 8.7 | Inhibition of human activated c-Met by PK/LDH coupled kinetic assay | 17964000 |
| Platelet-derived growth factor receptor alpha | IC50 | = | 28.0 | nM | 7.55 | Inhibition of PDGFR alpha phosphorylation in G292 cell | 16570914 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 202.0 | nM | 6.7 | Inhibition of c-kit receptor phosphorylation in M07e cell | 16570914 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16570914 | 10.1021/jm0506423 | Platelet-derived growth factor receptor alpha | 1 |
| 16570914 | 10.1021/jm0506423 | Mast/stem cell growth factor receptor Kit | 1 |
| 17964000 | 10.1016/j.ejmech.2007.08.011 | Hepatocyte growth factor receptor | 1 |
| 21641696 | 10.1016/j.ejmech.2011.05.031 | Hepatocyte growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine