Assay Detail
Functional
CHEMBL860933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFR alpha phosphorylation in G292 cell
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | G292 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of potent and selective inhibitors of PDGF receptor autophosphorylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.87 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203227 | — | — | 1 | 8.40 |
| CHEMBL202919 | — | — | 1 | 8.30 |
| CHEMBL380703 | — | — | 1 | 8.30 |
| CHEMBL203279 | — | — | 1 | 8.22 |
| CHEMBL425935 | — | — | 1 | 8.22 |
| CHEMBL205089 | — | — | 1 | 8.15 |
| CHEMBL378489 | — | — | 1 | 8.10 |
| CHEMBL204225 | — | — | 1 | 8.05 |
| CHEMBL205953 | — | — | 1 | 7.92 |
| CHEMBL204120 | — | — | 1 | 7.82 |
| CHEMBL425043 | — | — | 1 | 7.75 |
| CHEMBL205372 | — | — | 1 | 7.55 |
| CHEMBL382399 | — | — | 1 | 7.43 |
| CHEMBL205674 | — | — | 1 | 7.40 |
| CHEMBL204409 | — | — | 1 | 7.34 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203227 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL202919 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL380703 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL203279 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL425935 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL205089 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL378489 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL204225 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL205953 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL204120 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL425043 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL205372 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL382399 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL205674 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL204409 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL941 | IMATINIB | IC50 | = | 96.0 | nM | 7.02 |