Compound Detail
CHEMBL205953
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Basic Information
| ChEMBL ID | CHEMBL205953 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KVBWCMRDDFWCKD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
421.5
MW (Da)
5.50
ALogP
5
HBA
2
HBD
81.7
PSA (Ų)
0.55
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor alpha CHEMBL2007 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 7.66 | 7.66 | 22.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor alpha | IC50 | = | 12.0 | nM | 7.92 | Inhibition of PDGFR alpha phosphorylation in G292 cell | 16570914 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 22.0 | nM | 7.66 | Inhibition of c-kit receptor phosphorylation in M07e cell | 16570914 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16570914 | 10.1021/jm0506423 | Platelet-derived growth factor receptor alpha | 1 |
| 16570914 | 10.1021/jm0506423 | Mast/stem cell growth factor receptor Kit | 1 |
Data from ChEMBL 36 via Core Engine