Assay Detail
Binding
CHEMBL1827731
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to SERT
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.47 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1079460 | — | — | 1 | 8.64 |
| CHEMBL1822892 | LUBAZODONE HYDROCHLORIDE | -1.0 | 1 | 7.68 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.01 |
| CHEMBL623 | NEFAZODONE | 4.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1079460 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL1822892 | LUBAZODONE HYDROCHLORIDE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL623 | NEFAZODONE | Ki | = | 290.0 | nM | 6.54 |