Assay Detail
Functional
CHEMBL1831749
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Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.08 | 5.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.39 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.26 |
| CHEMBL1830069 | — | — | 1 | 4.85 |
| CHEMBL1830068 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1830069 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1830068 | — | EC50 | = | 16000.0 | nM | 4.80 |