Assay Detail
Functional
CHEMBL1831858
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Antiviral activity against 100 TCID50 wild type HIV1 LAI infected in human PBMC assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.30 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.50 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.47 |
| CHEMBL1830069 | — | — | 1 | 5.38 |
| CHEMBL1830068 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484 | ADEFOVIR | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1830069 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1830068 | — | EC50 | = | 14000.0 | nM | 4.85 |