Assay Detail
Functional
CHEMBL1831868
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Antiviral activity against HIV1 clade A/E isolate 2165 infected in human H9 cells assessed as inhibition of viral replication
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.45 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1830068 | — | — | 1 | 6.52 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 6.50 |
| CHEMBL1830069 | — | — | 1 | 6.47 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1830068 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1830069 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 510.0 | nM | 6.29 |