Assay Detail
Functional
CHEMBL1832517
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Antiproliferative activity against human A2780 cells after 96 hrs by celltiter 96 assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.58 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489332 | — | — | 1 | 7.51 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 7.46 |
| CHEMBL460963 | — | — | 1 | 6.96 |
| CHEMBL1830540 | — | — | 1 | 6.85 |
| CHEMBL491316 | — | — | 1 | 6.72 |
| CHEMBL1830536 | — | — | 1 | 6.70 |
| CHEMBL1830422 | — | — | 1 | 6.70 |
| CHEMBL1830541 | — | — | 1 | 6.68 |
| CHEMBL1830539 | — | — | 1 | 6.64 |
| CHEMBL1830537 | — | — | 1 | 6.64 |
| CHEMBL1830424 | — | — | 1 | 6.64 |
| CHEMBL1830420 | — | — | 1 | 6.62 |
| CHEMBL1830538 | — | — | 1 | 6.43 |
| CHEMBL1830396 | — | — | 1 | 6.42 |
| CHEMBL1830397 | — | — | 1 | 6.36 |
| CHEMBL3215861 | — | — | 1 | 6.32 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 6.17 |
| CHEMBL1830416 | — | — | 1 | 6.12 |
| CHEMBL1828648 | — | — | 1 | 5.91 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489332 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL460963 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1830540 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL491316 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1830536 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1830422 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1830541 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1830539 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1830537 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1830424 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1830420 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1830538 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL1830396 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1830397 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3215861 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1830416 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1828648 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1620.0 | nM | 5.79 |