Assay Detail
ADMET
CHEMBL1832816
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Inhibition of recombinant CYP2D6 after 30 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.50 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1830424 | — | — | 1 | 5.50 |
| CHEMBL3215861 | — | — | 1 | - |
| CHEMBL1830397 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1830424 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL3215861 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1830397 | — | IC50 | > | 10000.0 | nM | - |