Assay Detail
ADMET
CHEMBL1833288
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Inhibition of CYP3A4 in human liver microsomes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.47 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1831092 | — | — | 1 | 6.48 |
| CHEMBL517438 | — | — | 1 | 6.46 |
| CHEMBL1766005 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1831092 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL517438 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1766005 | — | IC50 | < | 100.0 | nM | - |