Assay Detail
Binding
CHEMBL1833366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat brain membrane after 120 mins
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.21 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1831159 | — | — | 1 | 8.67 |
| CHEMBL1830149 | — | — | 1 | 8.48 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.47 |
| CHEMBL270341 | — | — | 1 | 8.38 |
| CHEMBL1831158 | — | — | 1 | 8.27 |
| CHEMBL1831160 | — | — | 1 | 7.84 |
| CHEMBL1831167 | — | — | 1 | 7.46 |
| CHEMBL1831156 | — | — | 1 | 7.15 |
| CHEMBL1831164 | — | — | 1 | 7.04 |
| CHEMBL1831161 | — | — | 1 | 7.03 |
| CHEMBL1831157 | — | — | 1 | 6.85 |
| CHEMBL1831162 | — | — | 1 | 6.65 |
| CHEMBL1831168 | — | — | 1 | 6.55 |
| CHEMBL1831169 | — | — | 1 | 6.21 |
| CHEMBL1831163 | — | — | 1 | 6.15 |
| CHEMBL1831165 | — | — | 1 | 5.92 |
| CHEMBL1831166 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1831159 | — | Ki | = | 2.13 | nM | 8.67 |
| CHEMBL1830149 | — | Ki | = | 3.28 | nM | 8.48 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.35 | nM | 8.47 |
| CHEMBL270341 | — | Ki | = | 4.17 | nM | 8.38 |
| CHEMBL1831158 | — | Ki | = | 5.33 | nM | 8.27 |
| CHEMBL1831160 | — | Ki | = | 14.55 | nM | 7.84 |
| CHEMBL1831167 | — | Ki | = | 34.5 | nM | 7.46 |
| CHEMBL1831156 | — | Ki | = | 71.5 | nM | 7.15 |
| CHEMBL1831164 | — | Ki | = | 90.87 | nM | 7.04 |
| CHEMBL1831161 | — | Ki | = | 92.43 | nM | 7.03 |
| CHEMBL1831157 | — | Ki | = | 140.7 | nM | 6.85 |
| CHEMBL1831162 | — | Ki | = | 222.33 | nM | 6.65 |
| CHEMBL1831168 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL1831169 | — | Ki | = | 613.66 | nM | 6.21 |
| CHEMBL1831163 | — | Ki | = | 713.5 | nM | 6.15 |
| CHEMBL1831165 | — | Ki | = | 1202.0 | nM | 5.92 |
| CHEMBL1831166 | — | Ki | = | 2948.4 | nM | 5.53 |