Assay Detail
Binding
CHEMBL1837220
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine BuChE by Ellman's method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.99 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.68 |
| CHEMBL1766151 | — | — | 1 | 5.66 |
| CHEMBL1084213 | — | — | 1 | 5.58 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 5.44 |
| CHEMBL1834063 | — | — | 1 | 5.41 |
| CHEMBL1834074 | — | — | 1 | 5.12 |
| CHEMBL1834060 | — | — | 1 | 5.12 |
| CHEMBL1834061 | — | — | 1 | 5.04 |
| CHEMBL1834071 | — | — | 1 | 5.01 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | 4.0 | 1 | 4.90 |
| CHEMBL1834073 | — | — | 1 | 4.76 |
| CHEMBL1834067 | — | — | 1 | 4.75 |
| CHEMBL1834062 | — | — | 1 | 4.74 |
| CHEMBL1834069 | — | — | 1 | 4.62 |
| CHEMBL1834066 | — | — | 1 | 4.59 |
| CHEMBL1834068 | — | — | 1 | 4.58 |
| CHEMBL1834079 | — | — | 1 | 4.55 |
| CHEMBL1834064 | — | — | 1 | 4.48 |
| CHEMBL1834070 | — | — | 1 | 4.47 |
| CHEMBL1834078 | — | — | 1 | 4.22 |
| CHEMBL1834072 | — | — | 1 | 4.06 |
| CHEMBL1834077 | — | — | 1 | - |
| CHEMBL1834076 | — | — | 1 | - |
| CHEMBL1834075 | — | — | 1 | - |
| CHEMBL1834065 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1766151 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1084213 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1834063 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1834074 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1834060 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1834061 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL1834071 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL1555 | GALANTAMINE HYDROBROMIDE | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL1834073 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL1834067 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL1834062 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL1834069 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL1834066 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL1834068 | — | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL1834079 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL1834064 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL1834070 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL1834078 | — | IC50 | = | 59500.0 | nM | 4.22 |
| CHEMBL1834072 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL1834077 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1834076 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1834075 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1834065 | — | IC50 | > | 100000.0 | nM | - |