Assay Detail
Functional
CHEMBL1837640
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Antiproliferative activity against mouse BAF3 cell line transformed with TEL-FGFR3 construct after 48 hrs by luciferase bioluminescent assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.13 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834658 | — | — | 1 | 8.70 |
| CHEMBL1834657 | INFIGRATINIB PHOSPHATE | 4.0 | 1 | 8.70 |
| CHEMBL1834663 | — | — | 1 | 7.96 |
| CHEMBL1834662 | — | — | 1 | 7.85 |
| CHEMBL1834661 | — | — | 1 | 7.85 |
| CHEMBL1834660 | — | — | 1 | 7.57 |
| CHEMBL1834659 | — | — | 1 | 7.55 |
| CHEMBL1834656 | — | — | 1 | 6.93 |
| CHEMBL1834655 | — | — | 1 | 6.90 |
| CHEMBL1834603 | — | — | 1 | 6.20 |
| CHEMBL1833981 | — | — | 1 | 6.12 |
| CHEMBL1834653 | — | — | 1 | 6.08 |
| CHEMBL1834602 | — | — | 1 | 5.82 |
| CHEMBL1834654 | — | — | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834658 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1834657 | INFIGRATINIB PHOSPHATE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1834663 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1834662 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1834661 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1834660 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1834659 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1834656 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL1834655 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL1834603 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL1833981 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1834653 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL1834602 | — | IC50 | = | 1512.0 | nM | 5.82 |
| CHEMBL1834654 | — | IC50 | = | 2223.0 | nM | 5.65 |