Compound Detail
CHEMBL1834654
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Basic Information
| ChEMBL ID | CHEMBL1834654 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NVOHUTVLFUTBHX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
468.0
MW (Da)
4.28
ALogP
7
HBA
3
HBD
94.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 6.08 | 6.08 | 840.0 | 1 |
| BaF3 CHEMBL614524 | IC50 | 5.65 | 5.65 | 2223.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 840.0 | nM | 6.08 | Inhibition of GST-fusion FGFR3 K650E mutant using [gamma33P]ATP as substrate aft... | 21936542 |
| BaF3 | IC50 | = | 2223.0 | nM | 5.65 | Antiproliferative activity against mouse BAF3 cell line transformed with TEL-FGF... | 21936542 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21936542 | 10.1021/jm2006222 | BaF3 | 1 |
| 21936542 | 10.1021/jm2006222 | Fibroblast growth factor receptor 3 | 1 |
Data from ChEMBL 36 via Core Engine