Assay Detail
ADMET
CHEMBL1837643
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Inhibition of CYP2C9 using MFC as substrate
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.59 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834658 | — | — | 1 | 5.77 |
| CHEMBL1834661 | — | — | 1 | 5.40 |
| CHEMBL1834663 | — | — | 1 | - |
| CHEMBL1834662 | — | — | 1 | - |
| CHEMBL1834660 | — | — | 1 | - |
| CHEMBL1834659 | — | — | 1 | - |
| CHEMBL1834657 | INFIGRATINIB PHOSPHATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834658 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1834661 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1834663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1834662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1834660 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1834659 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1834657 | INFIGRATINIB PHOSPHATE | IC50 | > | 10000.0 | nM | - |