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Assay Detail

CHEMBL1837833

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP3A4
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Cytochrome P450 3A4 (CHEMBL340)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder.
Packiarajan M, Marzabadi MR, Desai M, Lu Y, Noble SA, Wong WC, Jubian V, Chandrasena G, Wolinsky TD, Zhong H, Walker MW, Wiborg O, Andersen K.
Bioorg Med Chem Lett (2011) 21 : 5436 -5441
PubMed 21782428 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.39 5.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1836317 1 5.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1836317 IC50 = 4100.0 nM 5.39