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Assay Detail

CHEMBL1839276

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Binding
Inhibition of ovine COX1 by enzyme immuno assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prostaglandin G/H synthase 1 (CHEMBL2949)
Type SINGLE PROTEIN
Organism Ovis aries

Publication

Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.
Abdur Rahim M, Praveen Rao PN, Bhardwaj A, Kaur J, Huang Z, Knaus EE.
Bioorg Med Chem Lett (2011) 21 : 6074 -6080
PubMed 21890358 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.31 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL25 ASPIRIN 4.0 1 6.52
CHEMBL1835477 1 6.16
CHEMBL521 IBUPROFEN 4.0 1 5.54
CHEMBL118 CELECOXIB 4.0 1 5.11
CHEMBL1835473 1 4.44
CHEMBL1835478 1 4.09
CHEMBL1835056 1 -
CHEMBL1835472 1 -
CHEMBL1835474 1 -
CHEMBL1835475 1 -
CHEMBL1835476 1 -
CHEMBL1835479 1 -
CHEMBL1835481 1 -
CHEMBL1835055 1 -
CHEMBL1835480 1 -
CHEMBL1835482 1 -
CHEMBL1835483 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL25 ASPIRIN IC50 = 300.0 nM 6.52
CHEMBL1835477 IC50 = 700.0 nM 6.16
CHEMBL521 IBUPROFEN IC50 = 2900.0 nM 5.54
CHEMBL118 CELECOXIB IC50 = 7700.0 nM 5.11
CHEMBL1835473 IC50 = 36000.0 nM 4.44
CHEMBL1835478 IC50 = 80300.0 nM 4.09
CHEMBL1835056 IC50 > 100000.0 nM -
CHEMBL1835472 IC50 > 100000.0 nM -
CHEMBL1835474 IC50 > 100000.0 nM -
CHEMBL1835475 IC50 > 100000.0 nM -
CHEMBL1835476 IC50 > 100000.0 nM -
CHEMBL1835479 IC50 > 100000.0 nM -
CHEMBL1835481 IC50 > 100000.0 nM -
CHEMBL1835055 IC50 > 100000.0 nM -
CHEMBL1835480 IC50 - -
CHEMBL1835482 IC50 - -
CHEMBL1835483 IC50 > 100000.0 nM -