Assay Detail

CHEMBL1839677

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Functional

Cytotoxicity against human DU145 cells by propidium iodide staining

ChEMBL ↗

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Target

DU-145 (CHEMBL613508) ↗

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DU-145 (CHEMBL613508) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target DU-145

CHEMBL613508

Anchored from Assay target.

Protein identity DU-145

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	DU-145
Confidence	1 — Organism
Curated By	Autocuration

Target

DU-145 (CHEMBL613508) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Hydrazidomycins, cytotoxic alkylhydrazides from Streptomycesatratus.

Ueberschaar N, Ndejouong Ble S, Ding L, Maier A, Fiebig HH, Hertweck C.
Bioorg Med Chem Lett (2011) 21 : 5839 -5841
PubMed 21868221 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.71	6.27

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1834207	HYDRAZIDOMYCIN A	—	1	6.27
CHEMBL1834208	HYDRAZIDOMYCIN B	—	1	5.14

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1834207	HYDRAZIDOMYCIN A	IC50	=	539.0	nM	6.27
CHEMBL1834208	HYDRAZIDOMYCIN B	IC50	=	7220.0	nM	5.14