Assay Detail
Functional
CHEMBL1840218
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Agonist activity at human beta3 receptor expressed in CHO cells assessed as cAMP accumulation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.40 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835855 | — | — | 1 | 8.60 |
| CHEMBL1835853 | — | — | 1 | 8.10 |
| CHEMBL1835856 | — | — | 1 | 7.90 |
| CHEMBL1835860 | — | — | 1 | 7.90 |
| CHEMBL1835857 | — | — | 1 | 7.80 |
| CHEMBL1835861 | — | — | 1 | 7.60 |
| CHEMBL1200811 | ARFORMOTEROL FUMARATE | — | 1 | 7.60 |
| CHEMBL1835858 | — | — | 1 | 7.50 |
| CHEMBL1835862 | — | — | 1 | 7.40 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 7.40 |
| CHEMBL1835859 | — | — | 1 | 7.00 |
| CHEMBL1835854 | — | — | 1 | 6.80 |
| CHEMBL1084647 | VILANTEROL ACETATE | — | 1 | 6.10 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835855 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL1835853 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1835856 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL1835860 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL1835857 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL1835861 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1200811 | ARFORMOTEROL FUMARATE | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1835858 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL1835862 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1835859 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1835854 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL1084647 | VILANTEROL ACETATE | EC50 | = | 794.33 | nM | 6.10 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 1258.93 | nM | 5.90 |