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Compound Detail

CHEMBL1835853

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CC(=O)O.NC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1

Basic Information

ChEMBL ID CHEMBL1835853
Phase Preclinical
Structure Type MOL
InChI Key QASZJZYYUMSAOE-UQIIZPHYSA-N
Parent Compound CHEMBL1852214
Active Moiety CHEMBL1852214
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

473.6
MW (Da)
3.60
ALogP
6
HBA
6
HBD
137.1
PSA (Ų)
0.19
QED
1
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H43N3O7
MW 533.67
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -0.20

Activity Summary

EC50 4 meas. best 9.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.1 9.1 0.8 1
Beta-2 adrenergic receptor
CHEMBL5414
EC50 8.6 8.6 2.5 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.1 8.1 7.9 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.2 7.2 63.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21925889 10.1016/j.bmc.2011.08.043 Beta-2 adrenergic receptor 5
21925889 10.1016/j.bmc.2011.08.043 Beta-1 adrenergic receptor 1
21925889 10.1016/j.bmc.2011.08.043 Beta-3 adrenergic receptor 1
21925889 10.1016/j.bmc.2011.08.043 Liver microsomes 1
21925889 10.1016/j.bmc.2011.08.043 Cavia porcellus 1
21925889 10.1016/j.bmc.2011.08.043 No relevant target 1

Data from ChEMBL 36 via Core Engine