Assay Detail
Functional
CHEMBL1840217
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta1 receptor expressed in CHO cells assessed as cAMP accumulation
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.44 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835857 | — | — | 1 | 8.10 |
| CHEMBL1835855 | — | — | 1 | 8.10 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 8.10 |
| CHEMBL1835860 | — | — | 1 | 8.00 |
| CHEMBL1835856 | — | — | 1 | 7.50 |
| CHEMBL1835858 | — | — | 1 | 7.50 |
| CHEMBL1835859 | — | — | 1 | 7.50 |
| CHEMBL1835854 | — | — | 1 | 7.50 |
| CHEMBL1835862 | — | — | 1 | 7.40 |
| CHEMBL1200811 | ARFORMOTEROL FUMARATE | — | 1 | 7.40 |
| CHEMBL1835861 | — | — | 1 | 7.30 |
| CHEMBL1835853 | — | — | 1 | 7.20 |
| CHEMBL1084647 | VILANTEROL ACETATE | — | 1 | 6.40 |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835857 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1835855 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL1835860 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1835856 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL1835858 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL1835859 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL1835854 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL1835862 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1200811 | ARFORMOTEROL FUMARATE | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL1835861 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL1835853 | — | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL1084647 | VILANTEROL ACETATE | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL1263 | SALMETEROL | EC50 | = | 794.33 | nM | 6.10 |