Assay Detail
Binding
CHEMBL1908783
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding constant for SLK kinase domain
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
STE20-like serine/threonine-protein kinase (CHEMBL4202) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Comprehensive analysis of kinase inhibitor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 72 | 6.66 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 10.62 |
| CHEMBL1230609 | FORETINIB | 2.0 | 1 | 8.52 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.33 |
| CHEMBL1908397 | KW-2449 | 1.0 | 1 | 7.89 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 7.75 |
| CHEMBL509032 | TAE-684 | — | 1 | 7.68 |
| CHEMBL491473 | CEDIRANIB | 3.0 | 1 | 7.66 |
| CHEMBL574738 | AST-487 | 1.0 | 1 | 7.64 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.58 |
| CHEMBL475251 | R-406 | 2.0 | 1 | 7.48 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.46 |
| CHEMBL502835 | NINTEDANIB | 4.0 | 1 | 7.29 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 7.25 |
| CHEMBL1908396 | — | — | 1 | 7.22 |
| CHEMBL180022 | NERATINIB | 4.0 | 1 | 7.18 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 7.09 |
| CHEMBL1241674 | — | — | 1 | 7.08 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 7.02 |
| CHEMBL384304 | RG-547 | 2.0 | 1 | 7.02 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 6.82 |
| CHEMBL377300 | BRIVANIB | 3.0 | 1 | 6.77 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.66 |
| CHEMBL477772 | PAZOPANIB | 4.0 | 1 | 6.62 |
| CHEMBL522892 | DOVITINIB | 3.0 | 1 | 6.52 |
| CHEMBL450786 | PHA-665752 | — | 1 | 6.46 |
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | 6.40 |
| CHEMBL223360 | LINIFANIB | 3.0 | 1 | 6.35 |
| CHEMBL1721885 | SU-014813 | 2.0 | 1 | 6.34 |
| CHEMBL558752 | RAF-265 | 2.0 | 1 | 6.29 |
| CHEMBL1287853 | FEDRATINIB | 4.0 | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | Kd | = | 0.024 | nM | 10.62 |
| CHEMBL1230609 | FORETINIB | Kd | = | 3.0 | nM | 8.52 |
| CHEMBL288441 | BOSUTINIB | Kd | = | 4.7 | nM | 8.33 |
| CHEMBL1908397 | KW-2449 | Kd | = | 13.0 | nM | 7.89 |
| CHEMBL601719 | CRIZOTINIB | Kd | = | 18.0 | nM | 7.75 |
| CHEMBL509032 | TAE-684 | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL491473 | CEDIRANIB | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL574738 | AST-487 | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL553 | ERLOTINIB | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL475251 | R-406 | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL603469 | LESTAURTINIB | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL502835 | NINTEDANIB | Kd | = | 51.0 | nM | 7.29 |
| CHEMBL535 | SUNITINIB | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL1908396 | — | Kd | = | 60.0 | nM | 7.22 |
| CHEMBL180022 | NERATINIB | Kd | = | 66.0 | nM | 7.18 |
| CHEMBL572878 | TOZASERTIB | Kd | = | 82.0 | nM | 7.09 |
| CHEMBL1241674 | — | Kd | = | 84.0 | nM | 7.08 |
| CHEMBL24828 | VANDETANIB | Kd | = | 95.0 | nM | 7.02 |
| CHEMBL384304 | RG-547 | Kd | = | 96.0 | nM | 7.02 |
| CHEMBL103667 | DORAMAPIMOD | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL377300 | BRIVANIB | Kd | = | 170.0 | nM | 6.77 |
| CHEMBL608533 | MIDOSTAURIN | Kd | = | 220.0 | nM | 6.66 |
| CHEMBL477772 | PAZOPANIB | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL522892 | DOVITINIB | Kd | = | 300.0 | nM | 6.52 |
| CHEMBL450786 | PHA-665752 | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL91829 | RUBOXISTAURIN | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL223360 | LINIFANIB | Kd | = | 450.0 | nM | 6.35 |
| CHEMBL1721885 | SU-014813 | Kd | = | 460.0 | nM | 6.34 |
| CHEMBL558752 | RAF-265 | Kd | = | 510.0 | nM | 6.29 |
| CHEMBL1287853 | FEDRATINIB | Kd | = | 680.0 | nM | 6.17 |
| CHEMBL1908395 | — | Kd | = | 720.0 | nM | 6.14 |
| CHEMBL5416410 | DASATINIB | Kd | = | 720.0 | nM | 6.14 |
| CHEMBL939 | GEFITINIB | Kd | = | 920.0 | nM | 6.04 |
| CHEMBL1336 | SORAFENIB | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL1289926 | AXITINIB | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL1908394 | GSK-461364 | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL572881 | MOTESANIB | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL525191 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL31965 | CANERTINIB | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL300138 | ENZASTAURIN | Kd | = | 3100.0 | nM | 5.51 |
| CHEMBL554 | LAPATINIB | Kd | = | 3300.0 | nM | 5.48 |
| CHEMBL1173655 | AFATINIB | Kd | = | 3700.0 | nM | 5.43 |
| CHEMBL386051 | — | Kd | = | 3700.0 | nM | 5.43 |
| CHEMBL10 | SB-203580 | Kd | = | 3700.0 | nM | 5.43 |
| CHEMBL513909 | BI-2536 | Kd | = | 4100.0 | nM | 5.39 |
| CHEMBL576982 | QUIZARTINIB | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL1230020 | PLX-4720 | Kd | = | 5100.0 | nM | 5.29 |
| CHEMBL445813 | AT-7519 | Kd | = | 5900.0 | nM | 5.23 |
| CHEMBL255863 | NILOTINIB | Kd | > | 10000.0 | nM | - |
| CHEMBL215152 | DEFOSBARASERTIB | Kd | > | 10000.0 | nM | - |