Assay Detail
Binding
CHEMBL1909180
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DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 5.32 | 6.87 |
| Ki | 871 | 5.77 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1618305 | NALOXONAZINE | — | 2 | 7.32 |
| CHEMBL19019 | NALTREXONE | 4.0 | 2 | 7.06 |
| CHEMBL841 | LOPERAMIDE | 4.0 | 2 | 6.50 |
| CHEMBL808 | ECONAZOLE | 4.0 | 2 | 6.29 |
| CHEMBL80 | NALOXONE | 4.0 | 2 | 6.29 |
| CHEMBL895 | NALBUPHINE | 4.0 | 2 | 6.18 |
| CHEMBL411 | DIETHYLSTILBESTROL | 4.0 | 2 | 6.02 |
| CHEMBL434063 | — | — | 2 | 5.95 |
| CHEMBL91 | MICONAZOLE | 4.0 | 2 | 5.92 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 2 | 5.83 |
| CHEMBL787 | MONTELUKAST | 4.0 | 2 | 5.77 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 2 | 5.76 |
| CHEMBL1262 | OXICONAZOLE | 4.0 | 2 | 5.73 |
| CHEMBL81 | RALOXIFENE | 4.0 | 2 | 5.63 |
| CHEMBL633 | AMIODARONE | 4.0 | 2 | 5.55 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 2 | 5.35 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 2 | 5.34 |
| CHEMBL83 | TAMOXIFEN | 4.0 | 2 | 5.33 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 5.13 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 5.07 |
| CHEMBL7002 | CIGLITAZONE | 2.0 | 2 | 5.02 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 2 | 5.00 |
| CHEMBL584 | NELFINAVIR | 4.0 | 2 | 4.63 |
| CHEMBL515914 | AZARIBINE | 4.0 | 2 | - |
| CHEMBL1200558 | BACITRACIN | 4.0 | 2 | - |
| CHEMBL388590 | BENZBROMARONE | 4.0 | 2 | - |
| CHEMBL1200396 | BUPIVACAINE HYDROCHLORIDE | 4.0 | 2 | - |
| CHEMBL1458880 | CADMIUM DICHLORIDE | — | 2 | - |
| CHEMBL14 | CARBACHOL | 4.0 | 2 | - |
| CHEMBL211501 | ANTIMYCIN A | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1618305 | NALOXONAZINE | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL19019 | NALTREXONE | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL1618305 | NALOXONAZINE | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL19019 | NALTREXONE | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL841 | LOPERAMIDE | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL80 | NALOXONE | Ki | = | 515.0 | nM | 6.29 |
| CHEMBL808 | ECONAZOLE | Ki | = | 508.0 | nM | 6.29 |
| CHEMBL895 | NALBUPHINE | Ki | = | 665.0 | nM | 6.18 |
| CHEMBL841 | LOPERAMIDE | IC50 | = | 896.0 | nM | 6.05 |
| CHEMBL411 | DIETHYLSTILBESTROL | Ki | = | 958.0 | nM | 6.02 |
| CHEMBL434063 | — | Ki | = | 1131.0 | nM | 5.95 |
| CHEMBL91 | MICONAZOLE | Ki | = | 1194.0 | nM | 5.92 |
| CHEMBL808 | ECONAZOLE | IC50 | = | 1442.0 | nM | 5.84 |
| CHEMBL428647 | PACLITAXEL | Ki | = | 1481.0 | nM | 5.83 |
| CHEMBL80 | NALOXONE | IC50 | = | 1461.0 | nM | 5.83 |
| CHEMBL787 | MONTELUKAST | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL104 | CLOTRIMAZOLE | Ki | = | 1755.0 | nM | 5.76 |
| CHEMBL1262 | OXICONAZOLE | Ki | = | 1871.2 | nM | 5.73 |
| CHEMBL895 | NALBUPHINE | IC50 | = | 1886.0 | nM | 5.72 |
| CHEMBL81 | RALOXIFENE | Ki | = | 2342.0 | nM | 5.63 |
| CHEMBL411 | DIETHYLSTILBESTROL | IC50 | = | 2718.0 | nM | 5.57 |
| CHEMBL633 | AMIODARONE | Ki | = | 2825.0 | nM | 5.55 |
| CHEMBL434063 | — | IC50 | = | 3209.0 | nM | 5.49 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 3387.0 | nM | 5.47 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4202.0 | nM | 5.38 |
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 4511.0 | nM | 5.35 |
| CHEMBL296419 | ASTEMIZOLE | Ki | = | 4575.0 | nM | 5.34 |
| CHEMBL83 | TAMOXIFEN | Ki | = | 4702.0 | nM | 5.33 |
| CHEMBL787 | MONTELUKAST | IC50 | = | 4795.0 | nM | 5.32 |
| CHEMBL104 | CLOTRIMAZOLE | IC50 | = | 4978.0 | nM | 5.30 |
| CHEMBL1262 | OXICONAZOLE | IC50 | = | 5308.1 | nM | 5.28 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 6644.0 | nM | 5.18 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 7365.0 | nM | 5.13 |
| CHEMBL633 | AMIODARONE | IC50 | = | 8014.0 | nM | 5.10 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 8473.0 | nM | 5.07 |
| CHEMBL7002 | CIGLITAZONE | Ki | = | 9481.0 | nM | 5.02 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 9930.0 | nM | 5.00 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 12797.0 | nM | 4.89 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 12979.0 | nM | 4.89 |
| CHEMBL83 | TAMOXIFEN | IC50 | = | 13339.0 | nM | 4.88 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 20894.0 | nM | 4.68 |
| CHEMBL584 | NELFINAVIR | Ki | = | 23319.0 | nM | 4.63 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 24036.0 | nM | 4.62 |
| CHEMBL7002 | CIGLITAZONE | IC50 | = | 26894.0 | nM | 4.57 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 28168.0 | nM | 4.55 |
| CHEMBL584 | NELFINAVIR | IC50 | = | 66149.0 | nM | 4.18 |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | - | — | - | |
| CHEMBL191 | LOSARTAN | Ki | - | — | - |