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Assay Detail

CHEMBL1909189

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
DRUGMATRIX: Potassium Channel [KATP] radioligand binding (ligand: [3H] Glyburide)
ChEMBL ↗
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type HIT-T15
Subcellular Membrane
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

DrugMatrix in vitro pharmacology data
Scott S. Auerbach, DrugMatrix¨ and ToxFX¨ Coordinator National Toxicology Program

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 871 6.90 8.42
Ki 871 7.85 9.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL472 GLYBURIDE 4.0 2 9.37
CHEMBL1481 GLIMEPIRIDE 4.0 2 7.96
CHEMBL1073 GLIPIZIDE 4.0 2 7.35
CHEMBL783 NATEGLINIDE 4.0 2 6.72
CHEMBL221753 BENZETHONIUM CHLORIDE 2.0 2 -
CHEMBL113 CAFFEINE 4.0 2 -
CHEMBL319244 CAFFEIC ACID PHENETHYL ESTER — 2 -
CHEMBL277474 ANTIPYRINE 3.0 2 -
CHEMBL415690 BETADEX 3.0 2 -
CHEMBL264374 BEZAFIBRATE 3.0 2 -
CHEMBL1077 BROMFENAC 4.0 2 -
CHEMBL894 BUPROPION 4.0 2 -
CHEMBL108 CARBAMAZEPINE 4.0 2 -
CHEMBL24 ATENOLOL 4.0 2 -
CHEMBL1598608 AZASETRON 2.0 2 -
CHEMBL1201346 BALSALAZIDE 4.0 2 -
CHEMBL31184 BENZO[DEF]CHRYSENE 0.5 2 -
CHEMBL701 BACLOFEN 4.0 2 -
CHEMBL1095699 AZASERINE 2.0 2 -
CHEMBL3084803 ASTROMICIN 2.0 2 -
CHEMBL1200396 BUPIVACAINE HYDROCHLORIDE 4.0 2 -
CHEMBL844 BRIMONIDINE 4.0 2 -
CHEMBL1231530 BETAMIPRON 2.0 2 -
CHEMBL12089 BERBERINE CHLORIDE 1.0 2 -
CHEMBL211501 ANTIMYCIN A — 2 -
CHEMBL14 CARBACHOL 4.0 2 -
CHEMBL1458880 CADMIUM DICHLORIDE — 2 -
CHEMBL388590 BENZBROMARONE 4.0 2 -
CHEMBL1200558 BACITRACIN 4.0 2 -
CHEMBL515914 AZARIBINE 4.0 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL472 GLYBURIDE Ki = 0.432 nM 9.37
CHEMBL472 GLYBURIDE IC50 = 3.804 nM 8.42
CHEMBL1481 GLIMEPIRIDE Ki = 11.0 nM 7.96
CHEMBL1073 GLIPIZIDE Ki = 45.0 nM 7.35
CHEMBL1481 GLIMEPIRIDE IC50 = 100.0 nM 7.00
CHEMBL783 NATEGLINIDE Ki = 189.0 nM 6.72
CHEMBL1073 GLIPIZIDE IC50 = 398.0 nM 6.40
CHEMBL783 NATEGLINIDE IC50 = 1667.0 nM 5.78
CHEMBL80 NALOXONE IC50 - — -
CHEMBL1909067 — IC50 - — -
CHEMBL80 NALOXONE Ki - — -
CHEMBL1221512 — IC50 - — -
CHEMBL1221512 — Ki - — -
CHEMBL480 LANSOPRAZOLE IC50 - — -
CHEMBL480 LANSOPRAZOLE Ki - — -
CHEMBL1201193 LEVOBUPIVACAINE IC50 - — -
CHEMBL503 LOVASTATIN Ki - — -
CHEMBL1909067 — Ki - — -
CHEMBL164290 N-NITROSODIETHYLAMINE Ki - — -
CHEMBL1373 MODAFINIL Ki - — -
CHEMBL1373 MODAFINIL IC50 - — -
CHEMBL91 MICONAZOLE Ki - — -
CHEMBL91 MICONAZOLE IC50 - — -
CHEMBL878 METOLAZONE Ki - — -
CHEMBL878 METOLAZONE IC50 - — -
CHEMBL1201151 MESTRANOL Ki - — -
CHEMBL164290 N-NITROSODIETHYLAMINE IC50 - — -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE Ki - — -
CHEMBL1354199 METHSCOPOLAMINE BROMIDE IC50 - — -
CHEMBL86304 MOCLOBEMIDE Ki - — -
CHEMBL1201151 MESTRANOL IC50 - — -
CHEMBL547 ISOTRETINOIN IC50 - — -
CHEMBL547 ISOTRETINOIN Ki - — -
CHEMBL191 LOSARTAN IC50 - — -
CHEMBL191 LOSARTAN Ki - — -
CHEMBL86 METOCLOPRAMIDE IC50 - — -
CHEMBL86 METOCLOPRAMIDE Ki - — -
CHEMBL6437 MIANSERIN IC50 - — -
CHEMBL6437 MIANSERIN Ki - — -
CHEMBL86304 MOCLOBEMIDE IC50 - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 Ki - — -
CHEMBL1618305 NALOXONAZINE IC50 - — -
CHEMBL1618305 NALOXONAZINE Ki - — -
CHEMBL2106399 KITASAMYCIN IC50 - — -
CHEMBL2106399 KITASAMYCIN Ki - — -
CHEMBL741 LAMOTRIGINE IC50 - — -
CHEMBL741 LAMOTRIGINE Ki - — -
CHEMBL1201237 LEVOBUNOLOL IC50 - — -
CHEMBL1201237 LEVOBUNOLOL Ki - — -
CHEMBL1909064 LIPOPOLYSACCHARIDE E. COLI O55:B5 IC50 - — -