Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1912974

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive binding affinity to rat androgen receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Androgen receptor (CHEMBL3072)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.
Nagata N, Miyakawa M, Amano S, Furuya K, Yamamoto N, Nejishima H, Inoguchi K.
Bioorg Med Chem Lett (2011) 21 : 6310 -6313
PubMed 21944856 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.57 8.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27769 STANOLONE 2.0 1 8.51
CHEMBL1684194 1 8.29
CHEMBL1910418 1 7.66
CHEMBL1910411 1 7.58
CHEMBL1909642 1 7.42
CHEMBL1910408 1 7.35
CHEMBL1910406 1 7.23
CHEMBL1910419 1 7.05
CHEMBL1910410 1 7.00
CHEMBL1910407 1 -
CHEMBL1910409 1 -
CHEMBL1910412 1 -
CHEMBL1910413 1 -
CHEMBL1910414 1 -
CHEMBL1910415 1 -
CHEMBL1910416 1 -
CHEMBL1910417 1 -
CHEMBL1910420 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27769 STANOLONE IC50 = 3.1 nM 8.51
CHEMBL1684194 IC50 = 5.1 nM 8.29
CHEMBL1910418 IC50 = 22.0 nM 7.66
CHEMBL1910411 IC50 = 26.0 nM 7.58
CHEMBL1909642 IC50 = 38.0 nM 7.42
CHEMBL1910408 IC50 = 45.0 nM 7.35
CHEMBL1910406 IC50 = 59.0 nM 7.23
CHEMBL1910419 IC50 = 89.0 nM 7.05
CHEMBL1910410 IC50 = 100.0 nM 7.00
CHEMBL1910407 IC50 > 1000.0 nM -
CHEMBL1910409 IC50 > 1000.0 nM -
CHEMBL1910412 IC50 > 1000.0 nM -
CHEMBL1910413 IC50 > 1000.0 nM -
CHEMBL1910414 IC50 > 1000.0 nM -
CHEMBL1910415 IC50 > 1000.0 nM -
CHEMBL1910416 IC50 > 1000.0 nM -
CHEMBL1910417 IC50 > 1000.0 nM -
CHEMBL1910420 IC50 > 1000.0 nM -