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Assay Detail

CHEMBL1912975

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at rat androgen receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Androgen receptor (CHEMBL3072)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.
Nagata N, Miyakawa M, Amano S, Furuya K, Yamamoto N, Nejishima H, Inoguchi K.
Bioorg Med Chem Lett (2011) 21 : 6310 -6313
PubMed 21944856 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 7.31 9.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27769 STANOLONE 2.0 1 9.01
CHEMBL1684194 1 8.64
CHEMBL1910411 1 7.89
CHEMBL1910419 1 7.34
CHEMBL1910418 1 7.12
CHEMBL1910406 1 7.02
CHEMBL1909642 1 6.72
CHEMBL1910410 1 6.09
CHEMBL1910408 1 5.92
CHEMBL1910407 1 -
CHEMBL1910409 1 -
CHEMBL1910412 1 -
CHEMBL1910413 1 -
CHEMBL1910414 1 -
CHEMBL1910415 1 -
CHEMBL1910416 1 -
CHEMBL1910417 1 -
CHEMBL1910420 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27769 STANOLONE EC50 = 0.97 nM 9.01
CHEMBL1684194 EC50 = 2.3 nM 8.64
CHEMBL1910411 EC50 = 13.0 nM 7.89
CHEMBL1910419 EC50 = 46.0 nM 7.34
CHEMBL1910418 EC50 = 75.0 nM 7.12
CHEMBL1910406 EC50 = 95.0 nM 7.02
CHEMBL1909642 EC50 = 190.0 nM 6.72
CHEMBL1910410 EC50 = 810.0 nM 6.09
CHEMBL1910408 EC50 = 1200.0 nM 5.92
CHEMBL1910407 EC50 - -
CHEMBL1910409 EC50 - -
CHEMBL1910412 EC50 - -
CHEMBL1910413 EC50 - -
CHEMBL1910414 EC50 - -
CHEMBL1910415 EC50 - -
CHEMBL1910416 EC50 - -
CHEMBL1910417 EC50 - -
CHEMBL1910420 EC50 - -