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Assay Detail

CHEMBL1912976

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at rat androgen receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Androgen receptor (CHEMBL3072)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.
Nagata N, Miyakawa M, Amano S, Furuya K, Yamamoto N, Nejishima H, Inoguchi K.
Bioorg Med Chem Lett (2011) 21 : 6310 -6313
PubMed 21944856 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.81 5.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1909642 1 5.82
CHEMBL1910419 1 5.10
CHEMBL1910410 1 4.85
CHEMBL1910418 1 4.54
CHEMBL1910408 1 4.36
CHEMBL1910406 1 4.21
CHEMBL1684194 1 -
CHEMBL1910407 1 -
CHEMBL1910409 1 -
CHEMBL1910411 1 -
CHEMBL27769 STANOLONE 2.0 1 -
CHEMBL1910413 1 -
CHEMBL1910414 1 -
CHEMBL1910415 1 -
CHEMBL1910416 1 -
CHEMBL1910417 1 -
CHEMBL1910420 1 -
CHEMBL1910412 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1909642 IC50 = 1500.0 nM 5.82
CHEMBL1910419 IC50 = 8000.0 nM 5.10
CHEMBL1910410 IC50 = 14000.0 nM 4.85
CHEMBL1910418 IC50 = 29000.0 nM 4.54
CHEMBL1910408 IC50 = 44000.0 nM 4.36
CHEMBL1910406 IC50 = 61000.0 nM 4.21
CHEMBL1684194 IC50 - -
CHEMBL1910407 IC50 - -
CHEMBL1910409 IC50 - -
CHEMBL1910411 IC50 > 100000.0 nM -
CHEMBL27769 STANOLONE IC50 - -
CHEMBL1910413 IC50 - -
CHEMBL1910414 IC50 - -
CHEMBL1910415 IC50 - -
CHEMBL1910416 IC50 - -
CHEMBL1910417 IC50 - -
CHEMBL1910420 IC50 - -
CHEMBL1910412 IC50 - -