Assay Detail
Binding
CHEMBL1912980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Dex from glucocorticoid receptor in Sprague-Dawley rat liver after 2 hrs by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroquinolines as a novel series of nonsteroidal selective androgen receptor modulators: structural requirements for better physicochemical and biological properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 7.66 |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 4.70 |
| CHEMBL1910411 | — | — | 1 | 4.31 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL27769 | STANOLONE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1910411 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 320000.0 | nM | - |