Assay Detail
Functional
CHEMBL1914133
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Antiinflammatory action in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production treated 30 mins before LPS challenge measured after 24 hrs by griess reaction
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pseudoguaianolides and guaianolides from Inula hupehensis as potential anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.23 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411908 | INUCHINENOLIDE C | — | 1 | 6.22 |
| CHEMBL486997 | BIGELOVIN | — | 1 | 6.05 |
| CHEMBL1911137 | — | — | 1 | 5.96 |
| CHEMBL1911134 | — | — | 1 | 5.82 |
| CHEMBL1911133 | — | — | 1 | 5.66 |
| CHEMBL1911128 | — | — | 1 | 5.46 |
| CHEMBL1911132 | — | — | 1 | 5.42 |
| CHEMBL515974 | ERGOLIDE | — | 1 | 5.41 |
| CHEMBL1911131 | — | — | 1 | 5.29 |
| CHEMBL1163771 | — | — | 1 | 5.20 |
| CHEMBL1911130 | — | — | 1 | 5.18 |
| CHEMBL1911141 | — | — | 1 | 5.10 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 5.10 |
| CHEMBL494255 | AROMATICIN | — | 1 | 5.09 |
| CHEMBL1644106 | CARPESIOLIN | — | 1 | 5.08 |
| CHEMBL1911138 | GRAVEOLIDE | — | 1 | 5.04 |
| CHEMBL1911136 | — | — | 1 | 5.04 |
| CHEMBL509159 | BURRODIN | — | 1 | 5.02 |
| CHEMBL1911140 | CONFERTIN | — | 1 | 5.01 |
| CHEMBL1911142 | INUCHINENOLIDE B | — | 1 | 5.00 |
| CHEMBL1911129 | — | — | 1 | 4.98 |
| CHEMBL1911139 | — | — | 1 | 4.77 |
| CHEMBL1911135 | — | — | 1 | 4.70 |
| CHEMBL521960 | INUVISCOLIDE | — | 1 | 4.66 |
| CHEMBL1644098 | GUAIANOLIDE | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411908 | INUCHINENOLIDE C | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL486997 | BIGELOVIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1911137 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1911134 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1911133 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1911128 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1911132 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL515974 | ERGOLIDE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1911131 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1163771 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1911130 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1911141 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL494255 | AROMATICIN | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1644106 | CARPESIOLIN | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1911138 | GRAVEOLIDE | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL1911136 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL509159 | BURRODIN | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1911140 | CONFERTIN | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1911142 | INUCHINENOLIDE B | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1911129 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1911139 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL1911135 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL521960 | INUVISCOLIDE | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL1644098 | GUAIANOLIDE | IC50 | = | 26800.0 | nM | 4.57 |