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Assay Detail

CHEMBL1918204

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Functional
Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium after 10 days by spectrophotometric analysis
ChEMBL ↗
66
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium tuberculosis
Confidence 1 — Organism
Curated By Autocuration

Target

Mycobacterium tuberculosis (CHEMBL360) ↗
Type ORGANISM
Organism Mycobacterium tuberculosis

Publication

Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis.
Ferreras JA, Gupta A, Amin ND, Basu A, Sinha BN, Worgall S, Jayaprakash V, Quadri LE.
Bioorg Med Chem Lett (2011) 21 : 6533 -6537
PubMed 21940166 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
MIC90 33 - -
IC50 33 4.69 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL64 ISONIAZID 4.0 2 7.16
CHEMBL1916867 — — 2 5.52
CHEMBL1916869 — — 2 5.40
CHEMBL1916850 — — 2 5.16
CHEMBL1916855 — — 2 5.10
CHEMBL1160853 — — 2 4.96
CHEMBL1169978 — — 2 4.70
CHEMBL1916841 — — 2 4.60
CHEMBL1916868 — — 2 4.51
CHEMBL1916852 — — 2 4.51
CHEMBL1916853 — — 2 4.43
CHEMBL1916848 — — 2 4.38
CHEMBL1160845 — — 2 4.37
CHEMBL1916851 — — 2 4.36
CHEMBL1916842 — — 2 4.34
CHEMBL1916854 — — 2 4.33
CHEMBL1916849 — — 2 4.28
CHEMBL1916847 — — 2 4.27
CHEMBL1916845 — — 2 4.11
CHEMBL1916857 — — 2 4.08
CHEMBL1916864 — — 2 4.01
CHEMBL1916863 — — 2 -
CHEMBL1916865 — — 2 -
CHEMBL1916843 — — 2 -
CHEMBL1916844 — — 2 -
CHEMBL1916846 — — 2 -
CHEMBL1916860 — — 2 -
CHEMBL1916862 — — 2 -
CHEMBL1916861 — — 2 -
CHEMBL1916866 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL64 ISONIAZID IC50 = 70.0 nM 7.16
CHEMBL1916867 — IC50 = 3000.0 nM 5.52
CHEMBL1916869 — IC50 = 4000.0 nM 5.40
CHEMBL1916850 — IC50 = 7000.0 nM 5.16
CHEMBL1916855 — IC50 = 8000.0 nM 5.10
CHEMBL1160853 — IC50 = 11000.0 nM 4.96
CHEMBL1169978 — IC50 = 20000.0 nM 4.70
CHEMBL1916841 — IC50 = 25000.0 nM 4.60
CHEMBL1916868 — IC50 = 31000.0 nM 4.51
CHEMBL1916852 — IC50 = 31000.0 nM 4.51
CHEMBL1916853 — IC50 = 37000.0 nM 4.43
CHEMBL1916848 — IC50 = 42000.0 nM 4.38
CHEMBL1160845 — IC50 = 43000.0 nM 4.37
CHEMBL1916851 — IC50 = 44000.0 nM 4.36
CHEMBL1916842 — IC50 = 46000.0 nM 4.34
CHEMBL1916854 — IC50 = 47000.0 nM 4.33
CHEMBL1916849 — IC50 = 53000.0 nM 4.28
CHEMBL1916847 — IC50 = 54000.0 nM 4.27
CHEMBL1916845 — IC50 = 77000.0 nM 4.11
CHEMBL1916857 — IC50 = 84000.0 nM 4.08
CHEMBL1916864 — IC50 = 97000.0 nM 4.01
CHEMBL1916843 — IC50 > 31000.0 nM -
CHEMBL64 ISONIAZID MIC90 = 200.0 nM -
CHEMBL1916851 — MIC90 = 66000.0 nM -
CHEMBL1916864 — MIC90 = 146000.0 nM -
CHEMBL1916863 — MIC90 > 16000.0 nM -
CHEMBL1916862 — MIC90 > 63000.0 nM -
CHEMBL1916861 — MIC90 > 63000.0 nM -
CHEMBL1916860 — MIC90 > 63000.0 nM -
CHEMBL1916859 — MIC90 > 63000.0 nM -
CHEMBL1916858 — MIC90 > 63000.0 nM -
CHEMBL1916857 — MIC90 > 500000.0 nM -
CHEMBL1916856 — MIC90 > 8000.0 nM -
CHEMBL1916855 — MIC90 = 16000.0 nM -
CHEMBL1916854 — MIC90 = 125000.0 nM -
CHEMBL1916844 — IC50 > 8000.0 nM -
CHEMBL1916846 — IC50 > 63000.0 nM -
CHEMBL1169978 — MIC90 > 31000.0 nM -
CHEMBL1916869 — MIC90 = 10000.0 nM -
CHEMBL1916856 — IC50 > 8000.0 nM -
CHEMBL1916858 — IC50 > 63000.0 nM -
CHEMBL1916859 — IC50 > 63000.0 nM -
CHEMBL1916860 — IC50 > 63000.0 nM -
CHEMBL1160853 — MIC90 = 222000.0 nM -
CHEMBL1916866 — IC50 > 500000.0 nM -
CHEMBL1916865 — IC50 > 8000.0 nM -
CHEMBL1916863 — IC50 > 16000.0 nM -
CHEMBL1916862 — IC50 > 63000.0 nM -
CHEMBL1160845 — MIC90 = 222000.0 nM -
CHEMBL1916861 — IC50 > 63000.0 nM -