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Compound Detail

CHEMBL1160853

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N/C(=N\O)N/N=C/c1ccccc1O

Basic Information

ChEMBL ID CHEMBL1160853
Phase Preclinical
Structure Type MOL
InChI Key XKXGOQZSTRVCBQ-BJMVGYQFSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

194.2
MW (Da)
0.02
ALogP
4
HBA
4
HBD
103.2
PSA (Ų)
0.23
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H10N4O2
MW 194.19
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness -0.84

Activity Summary

IC50 5 meas. best 4.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mycobacterium tuberculosis
CHEMBL360
IC50 4.96 4.89 11000.0 2
Yersinia pestis
CHEMBL614597
IC50 4.16 4.16 70000.0 1
HL-60
CHEMBL383
IC50 4.02 4.02 95000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21940166 10.1016/j.bmcl.2011.08.052 Yersinia pestis 7
21940166 10.1016/j.bmcl.2011.08.052 Mycobacterium tuberculosis 7
15163191 10.1021/jm031127c Xanthine dehydrogenase/oxidase 1
21536434 10.1016/j.bmcl.2011.04.009 HL-60 1
21536434 10.1016/j.bmcl.2011.04.009 HeLa 1
21536434 10.1016/j.bmcl.2011.04.009 Vero 1

Data from ChEMBL 36 via Core Engine