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Assay Detail

CHEMBL1918345

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimicrobial activity against Yersinia pestis KIM6-2082.1+ in PMHD medium after 26 hrs by spectrophotometric analysis
ChEMBL ↗
66
Total Activities
33
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Yersinia pestis
Confidence 1 — Organism
Curated By Autocuration

Target

Yersinia pestis (CHEMBL614597) ↗
Type ORGANISM
Organism Yersinia pestis

Publication

Chemical scaffolds with structural similarities to siderophores of nonribosomal peptide-polyketide origin as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis.
Ferreras JA, Gupta A, Amin ND, Basu A, Sinha BN, Worgall S, Jayaprakash V, Quadri LE.
Bioorg Med Chem Lett (2011) 21 : 6533 -6537
PubMed 21940166 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
MIC90 33 - -
IC50 33 5.22 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1169978 — — 2 7.40
CHEMBL372795 STREPTOMYCIN 4.0 2 6.00
CHEMBL1916853 — — 2 5.40
CHEMBL1916867 — — 2 5.40
CHEMBL1916854 — — 2 5.30
CHEMBL1916851 — — 2 5.16
CHEMBL1916847 — — 2 5.10
CHEMBL1916859 — — 2 5.10
CHEMBL1916841 — — 2 5.05
CHEMBL1916848 — — 2 4.89
CHEMBL1916842 — — 2 4.70
CHEMBL1916869 — — 2 4.21
CHEMBL1160853 — — 2 4.16
CHEMBL1916860 — — 2 -
CHEMBL1916865 — — 2 -
CHEMBL1916858 — — 2 -
CHEMBL1916857 — — 2 -
CHEMBL1916856 — — 2 -
CHEMBL1916855 — — 2 -
CHEMBL1916866 — — 2 -
CHEMBL1916868 — — 2 -
CHEMBL1916864 — — 2 -
CHEMBL1916850 — — 2 -
CHEMBL1916849 — — 2 -
CHEMBL1916846 — — 2 -
CHEMBL1916845 — — 2 -
CHEMBL1916844 — — 2 -
CHEMBL1916843 — — 2 -
CHEMBL1160845 — — 2 -
CHEMBL1916852 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1169978 — IC50 = 40.0 nM 7.40
CHEMBL372795 STREPTOMYCIN IC50 = 1000.0 nM 6.00
CHEMBL1916853 — IC50 = 4000.0 nM 5.40
CHEMBL1916867 — IC50 = 4000.0 nM 5.40
CHEMBL1916854 — IC50 = 5000.0 nM 5.30
CHEMBL1916851 — IC50 = 7000.0 nM 5.16
CHEMBL1916847 — IC50 = 8000.0 nM 5.10
CHEMBL1916859 — IC50 = 8000.0 nM 5.10
CHEMBL1916841 — IC50 = 9000.0 nM 5.05
CHEMBL1916848 — IC50 = 13000.0 nM 4.89
CHEMBL1916842 — IC50 = 20000.0 nM 4.70
CHEMBL1916869 — IC50 = 61000.0 nM 4.21
CHEMBL1160853 — IC50 = 70000.0 nM 4.16
CHEMBL1916849 — IC50 = 181000.0 nM -
CHEMBL1916854 — MIC90 = 21000.0 nM -
CHEMBL1169978 — MIC90 = 200.0 nM -
CHEMBL1916846 — IC50 > 31000.0 nM -
CHEMBL1916845 — IC50 > 250000.0 nM -
CHEMBL1916844 — IC50 > 16000.0 nM -
CHEMBL1916843 — IC50 > 31000.0 nM -
CHEMBL1916864 — MIC90 > 250000.0 nM -
CHEMBL1916850 — MIC90 > 63000.0 nM -
CHEMBL1916863 — MIC90 > 16000.0 nM -
CHEMBL1916862 — MIC90 > 31000.0 nM -
CHEMBL1916861 — MIC90 > 31000.0 nM -
CHEMBL1916860 — MIC90 > 16000.0 nM -
CHEMBL1916859 — MIC90 > 31000.0 nM -
CHEMBL1916858 — MIC90 > 31000.0 nM -
CHEMBL1916857 — MIC90 > 31000.0 nM -
CHEMBL1916856 — MIC90 > 8000.0 nM -
CHEMBL1916855 — MIC90 > 16000.0 nM -
CHEMBL1916868 — MIC90 = 388000.0 nM -
CHEMBL1916855 — IC50 > 16000.0 nM -
CHEMBL1916867 — MIC90 = 15000.0 nM -
CHEMBL1916866 — IC50 > 500000.0 nM -
CHEMBL1916865 — IC50 > 4000.0 nM -
CHEMBL1916864 — IC50 > 250000.0 nM -
CHEMBL1916863 — IC50 > 16000.0 nM -
CHEMBL1916862 — IC50 > 31000.0 nM -
CHEMBL1916861 — IC50 > 31000.0 nM -
CHEMBL1916860 — IC50 > 16000.0 nM -
CHEMBL1916850 — IC50 > 62000.0 nM -
CHEMBL1916858 — IC50 > 31000.0 nM -
CHEMBL1916857 — IC50 > 31000.0 nM -
CHEMBL1916856 — IC50 > 8000.0 nM -
CHEMBL372795 STREPTOMYCIN MIC90 = 1000.0 nM -
CHEMBL1916869 — MIC90 = 116000.0 nM -
CHEMBL1160853 — MIC90 = 250000.0 nM -
CHEMBL1916852 — IC50 > 125000.0 nM -
CHEMBL1160845 — MIC90 > 500000.0 nM -