Assay Detail

CHEMBL1918874

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to human Hsp90beta after overnight incubation by fluorescence polarization assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Heat shock protein HSP 90-beta (CHEMBL4303) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Heat shock protein HSP 90-beta (CHEMBL4303) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Heat shock protein HSP 90-beta

CHEMBL4303

Anchored from Assay target.

Protein identity Heat shock protein HSP 90-beta

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Heat shock protein HSP 90-beta (CHEMBL4303) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.

Vallée F, Carrez C, Pilorge F, Dupuy A, Parent A, Bertin L, Thompson F, Ferrari P, Fassy F, Lamberton A, Thomas A, Arrebola R, Guerif S, Rohaut A, Certal V, Ruxer JM, Gouyon T, Delorme C, Jouanen A, Dumas J, Grépin C, Combeau C, Goulaouic H, Dereu N, Mikol V, Mailliet P, Minoux H.
J Med Chem (2011) 54 : 7206 -7219
PubMed 21972823 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
K	2	-	-
Kd	2	8.80	9.46

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1917878	—	—	2	9.46
CHEMBL109480	TANESPIMYCIN	3.0	2	8.14

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1917878	—	Kd	=	0.35	nM	9.46
CHEMBL109480	TANESPIMYCIN	Kd	=	7.3	nM	8.14
CHEMBL1917878	—	K	=	1.8	nM	-
CHEMBL109480	TANESPIMYCIN	K	=	61.0	nM	-