Assay Detail
Binding
CHEMBL1919014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP]
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915636 | — | — | 1 | 9.00 |
| CHEMBL1915644 | — | — | 1 | 9.00 |
| CHEMBL1915633 | — | — | 1 | 9.00 |
| CHEMBL1914471 | — | — | 1 | 8.70 |
| CHEMBL1915445 | — | — | 1 | 8.70 |
| CHEMBL1915647 | — | — | 1 | 8.70 |
| CHEMBL1915646 | — | — | 1 | 8.70 |
| CHEMBL1915442 | — | — | 1 | 8.52 |
| CHEMBL1915651 | — | — | 1 | 8.40 |
| CHEMBL1915650 | — | — | 1 | 8.40 |
| CHEMBL1915648 | — | — | 1 | 8.30 |
| CHEMBL1915645 | — | — | 1 | 8.30 |
| CHEMBL1915443 | — | — | 1 | 8.22 |
| CHEMBL1915438 | — | — | 1 | 8.22 |
| CHEMBL1915638 | — | — | 1 | 8.22 |
| CHEMBL1915448 | — | — | 1 | 8.15 |
| CHEMBL1915634 | — | — | 1 | 8.10 |
| CHEMBL1915635 | — | — | 1 | 8.10 |
| CHEMBL1915428 | — | — | 1 | 8.10 |
| CHEMBL1915643 | — | — | 1 | 8.10 |
| CHEMBL1915649 | — | — | 1 | 8.00 |
| CHEMBL1915433 | — | — | 1 | 8.00 |
| CHEMBL1915436 | — | — | 1 | 8.00 |
| CHEMBL1915639 | — | — | 1 | 8.00 |
| CHEMBL1915640 | — | — | 1 | 8.00 |
| CHEMBL1915637 | — | — | 1 | 7.92 |
| CHEMBL1915449 | — | — | 1 | 7.92 |
| CHEMBL1915641 | — | — | 1 | 7.92 |
| CHEMBL1915439 | — | — | 1 | 7.82 |
| CHEMBL1915441 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915636 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1915644 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1915633 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1914471 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1915445 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1915647 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1915646 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1915442 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1915651 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1915650 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1915648 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1915645 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1915438 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1915638 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1915443 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1915448 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1915634 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1915635 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1915428 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1915643 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1915649 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1915433 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1915436 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1915639 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1915640 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1915637 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1915641 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1915449 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1915439 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1915441 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1915422 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1915426 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1915642 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1915429 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1915437 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1915430 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1915434 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1915444 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1915446 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1915421 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1915431 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1915440 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1915424 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1915435 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL1649765 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL1915447 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL1915427 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL1915425 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL1915432 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 186.0 | nM | 6.73 |