Compound Detail
CHEMBL1915447
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Basic Information
| ChEMBL ID | CHEMBL1915447 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FWRFIFBHBDJVET-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
456.8
MW (Da)
5.86
ALogP
6
HBA
2
HBD
88.6
PSA (Ų)
0.33
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 7.35 | 7.35 | 45.0 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 6.95 | 6.95 | 113.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 45.0 | nM | 7.35 | Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometr... | 21982499 |
| Serine/threonine-protein kinase pim-2 | IC50 | = | 113.0 | nM | 6.95 | Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometr... | 21982499 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21982499 | 10.1016/j.bmcl.2011.09.059 | Serine/threonine-protein kinase pim-1 | 1 |
| 21982499 | 10.1016/j.bmcl.2011.09.059 | Serine/threonine-protein kinase pim-2 | 1 |
Data from ChEMBL 36 via Core Engine