Assay Detail
Binding
CHEMBL1919187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transactivation activity at glucocorticoid receptor in rat H4II-E cells assessed as induction of tyrosine amino transferase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | H4II-E |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Steroidal C-21 mercapto derivatives as dissociated steroids: discovery of an inhaled dissociated steroid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.14 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1473 | FLUTICASONE PROPIONATE | 4.0 | 1 | 9.12 |
| CHEMBL1917414 | — | — | 1 | 7.73 |
| CHEMBL1917246 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1473 | FLUTICASONE PROPIONATE | EC50 | = | 0.76 | nM | 9.12 |
| CHEMBL1917414 | — | EC50 | = | 18.7 | nM | 7.73 |
| CHEMBL1917246 | — | EC50 | = | 27.0 | nM | 7.57 |