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Assay Detail

CHEMBL1920540

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-ketanserin from 5-HT2A receptor in rat cortex by liquid scintillation counting
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL322)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.
Zajdel P, Marciniec K, Maślankiewicz A, Paluchowska MH, Satała G, Partyka A, Jastrzębska-Więsek M, Wróbel D, Wesołowska A, Duszyńska B, Bojarski AJ, Pawłowski M.
Bioorg Med Chem (2011) 19 : 6750 -6759
PubMed 22001327 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 5.36 5.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1917355 1 5.88
CHEMBL1917348 1 5.83
CHEMBL1917344 1 5.79
CHEMBL1917360 1 5.75
CHEMBL1917342 1 5.55
CHEMBL1917358 1 5.29
CHEMBL1917359 1 5.20
CHEMBL1917347 1 5.08
CHEMBL1917346 1 5.06
CHEMBL1917350 1 4.76
CHEMBL1917349 1 4.76
CHEMBL1917345 1 -
CHEMBL1917351 1 -
CHEMBL1917352 1 -
CHEMBL1917353 1 -
CHEMBL1917354 1 -
CHEMBL1917343 1 -
CHEMBL1917356 1 -
CHEMBL1917357 1 -
CHEMBL1917341 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1917355 Ki = 1321.0 nM 5.88
CHEMBL1917348 Ki = 1462.0 nM 5.83
CHEMBL1917344 Ki = 1640.0 nM 5.79
CHEMBL1917360 Ki = 1790.0 nM 5.75
CHEMBL1917342 Ki = 2842.0 nM 5.55
CHEMBL1917358 Ki = 5093.0 nM 5.29
CHEMBL1917359 Ki = 6281.0 nM 5.20
CHEMBL1917347 Ki = 8246.0 nM 5.08
CHEMBL1917346 Ki = 8635.0 nM 5.06
CHEMBL1917350 Ki = 17480.0 nM 4.76
CHEMBL1917349 Ki = 17390.0 nM 4.76
CHEMBL1917345 Ki - -
CHEMBL1917351 Ki - -
CHEMBL1917352 Ki - -
CHEMBL1917353 Ki - -
CHEMBL1917354 Ki - -
CHEMBL1917343 Ki - -
CHEMBL1917356 Ki - -
CHEMBL1917357 Ki - -
CHEMBL1917341 Ki - -