Assay Detail
Functional
CHEMBL1921285
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Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-induced TNFalpha production after 5 hrs by ELISA method
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.87 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1916520 | — | — | 1 | 9.33 |
| CHEMBL1916528 | — | — | 1 | 9.15 |
| CHEMBL1738839 | — | — | 1 | 8.92 |
| CHEMBL1916519 | — | — | 1 | 8.85 |
| CHEMBL1916361 | — | — | 1 | 8.82 |
| CHEMBL1916525 | — | — | 1 | 8.72 |
| CHEMBL1916527 | — | — | 1 | 8.70 |
| CHEMBL1916360 | — | — | 1 | 8.60 |
| CHEMBL1916529 | — | — | 1 | 8.49 |
| CHEMBL1916523 | — | — | 1 | 8.43 |
| CHEMBL1916530 | — | — | 1 | 8.41 |
| CHEMBL1916349 | — | — | 1 | 7.85 |
| CHEMBL1916531 | — | — | 1 | 7.82 |
| CHEMBL1916522 | — | — | 1 | 7.80 |
| CHEMBL1916521 | — | — | 1 | 7.46 |
| CHEMBL1916359 | — | — | 1 | 7.43 |
| CHEMBL1916526 | — | — | 1 | 7.39 |
| CHEMBL1916346 | — | — | 1 | 7.30 |
| CHEMBL1916345 | — | — | 1 | 6.90 |
| CHEMBL1916524 | — | — | 1 | 6.90 |
| CHEMBL1916358 | — | — | 1 | 6.86 |
| CHEMBL1916347 | — | — | 1 | 6.84 |
| CHEMBL1916344 | — | — | 1 | 6.73 |
| CHEMBL1916350 | — | — | 1 | 6.72 |
| CHEMBL1916351 | — | — | 1 | 6.31 |
| CHEMBL1916352 | — | — | 1 | - |
| CHEMBL1916353 | — | — | 1 | - |
| CHEMBL1916348 | — | — | 1 | - |
| CHEMBL1916354 | — | — | 1 | - |
| CHEMBL1916355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1916520 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL1916528 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1738839 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1916519 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1916361 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1916525 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1916527 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1916360 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1916529 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1916523 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1916530 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1916349 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1916531 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1916522 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1916521 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1916359 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1916526 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1916346 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1916345 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL1916524 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL1916358 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL1916347 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL1916344 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL1916350 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1916351 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL1916352 | — | IC50 | - | — | - | |
| CHEMBL1916353 | — | IC50 | - | — | - | |
| CHEMBL1916348 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1916354 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1916355 | — | IC50 | - | — | - | |
| CHEMBL1916356 | — | IC50 | - | — | - | |
| CHEMBL1916357 | — | IC50 | - | — | - | |
| CHEMBL1914478 | — | IC50 | - | — | - | |
| CHEMBL1916343 | — | IC50 | - | — | - |