Assay Detail
Functional
CHEMBL1924914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against blood stream form of Trypanosoma brucei rhodesiense STIB 900 infected in rat L6 cells after 72 hrs by alamar blue assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.68 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.00 |
| CHEMBL1922442 | — | — | 1 | 6.93 |
| CHEMBL1922426 | — | — | 1 | 6.87 |
| CHEMBL1922441 | — | — | 1 | 6.71 |
| CHEMBL1922462 | — | — | 1 | 6.57 |
| CHEMBL1922440 | — | — | 1 | 6.51 |
| CHEMBL1922448 | — | — | 1 | 6.36 |
| CHEMBL1922460 | — | — | 1 | 6.33 |
| CHEMBL1922445 | — | — | 1 | 6.25 |
| CHEMBL1922428 | — | — | 1 | 6.22 |
| CHEMBL1922425 | — | — | 1 | 6.21 |
| CHEMBL1922439 | — | — | 1 | 6.21 |
| CHEMBL1922449 | — | — | 1 | 6.05 |
| CHEMBL1922459 | — | — | 1 | 6.04 |
| CHEMBL1922427 | — | — | 1 | 6.00 |
| CHEMBL1922458 | — | — | 1 | 5.98 |
| CHEMBL3142410 | — | — | 1 | 5.92 |
| CHEMBL3142409 | — | — | 1 | 5.86 |
| CHEMBL1922429 | — | — | 1 | 5.86 |
| CHEMBL1922444 | — | — | 1 | 5.85 |
| CHEMBL1922430 | — | — | 1 | 5.73 |
| CHEMBL1922446 | — | — | 1 | 5.66 |
| CHEMBL1922437 | — | — | 1 | 5.65 |
| CHEMBL1922447 | — | — | 1 | 5.65 |
| CHEMBL1922433 | — | — | 1 | 5.56 |
| CHEMBL1922431 | — | — | 1 | 5.46 |
| CHEMBL1922461 | — | — | 1 | 5.44 |
| CHEMBL1922432 | — | — | 1 | 5.41 |
| CHEMBL3142411 | — | — | 1 | 5.27 |
| CHEMBL1922453 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1922442 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL1922426 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL1922441 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL1922462 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL1922440 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL1922448 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL1922460 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL1922445 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL1922428 | — | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL1922425 | — | IC50 | = | 611.0 | nM | 6.21 |
| CHEMBL1922439 | — | IC50 | = | 621.0 | nM | 6.21 |
| CHEMBL1922449 | — | IC50 | = | 882.0 | nM | 6.05 |
| CHEMBL1922459 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL1922427 | — | IC50 | = | 996.0 | nM | 6.00 |
| CHEMBL1922458 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3142410 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3142409 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL1922429 | — | IC50 | = | 1397.0 | nM | 5.86 |
| CHEMBL1922444 | — | IC50 | = | 1417.0 | nM | 5.85 |
| CHEMBL1922430 | — | IC50 | = | 1872.0 | nM | 5.73 |
| CHEMBL1922446 | — | IC50 | = | 2191.0 | nM | 5.66 |
| CHEMBL1922447 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL1922437 | — | IC50 | = | 2257.0 | nM | 5.65 |
| CHEMBL1922433 | — | IC50 | = | 2756.0 | nM | 5.56 |
| CHEMBL1922431 | — | IC50 | = | 3455.0 | nM | 5.46 |
| CHEMBL1922461 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL1922432 | — | IC50 | = | 3922.0 | nM | 5.41 |
| CHEMBL3142411 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL1922453 | — | IC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL1922454 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL1922456 | — | IC50 | = | 8560.0 | nM | 5.07 |
| CHEMBL1922435 | — | IC50 | = | 10271.0 | nM | 4.99 |
| CHEMBL1922436 | — | IC50 | = | 11782.0 | nM | 4.93 |
| CHEMBL1922450 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL1922457 | — | IC50 | = | 14230.0 | nM | 4.85 |
| CHEMBL1922434 | — | IC50 | = | 15160.0 | nM | 4.82 |
| CHEMBL3215875 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL1922438 | — | IC50 | = | 15460.0 | nM | 4.81 |
| CHEMBL1922452 | — | IC50 | = | 21570.0 | nM | 4.67 |
| CHEMBL1922443 | — | IC50 | = | 21820.0 | nM | 4.66 |
| CHEMBL1922451 | — | IC50 | = | 23040.0 | nM | 4.64 |
| CHEMBL1922455 | — | IC50 | = | 32300.0 | nM | 4.49 |