Compound Detail
CHEMBL1922437
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Basic Information
| ChEMBL ID | CHEMBL1922437 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZNQMYSHKPGOSRI-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1963453 |
| Active Moiety | CHEMBL1963453 |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
406.8
MW (Da)
3.30
ALogP
9
HBA
1
HBD
117.2
PSA (Ų)
0.25
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma cruzi CHEMBL368 | IC50 | 6.01 | 6.01 | 968.0 | 1 |
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 5.65 | 5.65 | 2257.0 | 1 |
| Leishmania donovani CHEMBL367 | IC50 | 5.44 | 5.44 | 3630.0 | 1 |
| L6 CHEMBL614793 | IC50 | 4.78 | 4.78 | 16480.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma cruzi | IC50 | = | 968.0 | nM | 6.01 | Antitrypanosomal activity against blood stream form of Trypanosoma cruzi Tulahue... | 22023653 |
| Trypanosoma brucei rhodesiense | IC50 | = | 2257.0 | nM | 5.65 | Antitrypanosomal activity against blood stream form of Trypanosoma brucei rhodes... | 22023653 |
| Leishmania donovani | IC50 | = | 3630.0 | nM | 5.44 | Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes ... | 22023653 |
| L6 | IC50 | = | 16480.0 | nM | 4.78 | Cytotoxicity against rat L6 cells after 72 hrs by alamar blue assay | 22023653 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22023653 | 10.1021/jm201215n | Unchecked | 3 |
| 22023653 | 10.1021/jm201215n | Trypanosoma brucei rhodesiense | 1 |
| 22023653 | 10.1021/jm201215n | Trypanosoma cruzi | 1 |
| 22023653 | 10.1021/jm201215n | Leishmania donovani | 1 |
| 22023653 | 10.1021/jm201215n | L6 | 1 |
Data from ChEMBL 36 via Core Engine