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Assay Detail

CHEMBL1930611

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate after 15 mins by scintillation counting
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Casein kinase II subunit alpha' (CHEMBL4070)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

CK2α and CK2α' subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives.
Janeczko M, Orzeszko A, Kazimierczuk Z, Szyszka R, Baier A.
Eur J Med Chem (2012) 47 : 345 -350
PubMed 22115617 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.98 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1928903 1 7.46
CHEMBL223082 1 7.43
CHEMBL593153 1 7.21
CHEMBL1233807 1 7.18
CHEMBL595730 1 7.15
CHEMBL610448 1 7.11
CHEMBL1928907 1 7.08
CHEMBL1928904 1 7.06
CHEMBL1928906 1 7.00
CHEMBL375230 1 6.96
CHEMBL376505 1 6.95
CHEMBL1928909 1 6.86
CHEMBL1928908 1 6.73
CHEMBL1928905 1 6.70
CHEMBL373937 1 6.57
CHEMBL594575 1 6.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1928903 Ki = 35.0 nM 7.46
CHEMBL223082 Ki = 37.0 nM 7.43
CHEMBL593153 Ki = 62.0 nM 7.21
CHEMBL1233807 Ki = 66.0 nM 7.18
CHEMBL595730 Ki = 71.0 nM 7.15
CHEMBL610448 Ki = 78.0 nM 7.11
CHEMBL1928907 Ki = 83.0 nM 7.08
CHEMBL1928904 Ki = 88.0 nM 7.06
CHEMBL1928906 Ki = 100.0 nM 7.00
CHEMBL375230 Ki = 109.0 nM 6.96
CHEMBL376505 Ki = 112.0 nM 6.95
CHEMBL1928909 Ki = 139.0 nM 6.86
CHEMBL1928908 Ki = 188.0 nM 6.73
CHEMBL1928905 Ki = 200.0 nM 6.70
CHEMBL373937 Ki = 270.0 nM 6.57
CHEMBL594575 Ki = 609.0 nM 6.21