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Compound Detail

CHEMBL595730

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Ic1c(I)c(I)c2[nH]cnc2c1I

Basic Information

ChEMBL ID CHEMBL595730
Phase Preclinical
Structure Type MOL
InChI Key ZUHFPYANLLWSJR-UHFFFAOYSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

621.7
MW (Da)
3.98
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.27
QED
1
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C7H2I4N2
MW 621.72
Aromatic Rings 2
Heavy Atoms 13
NP-Likeness -0.39

Activity Summary

Ki 5 meas. best 7.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Casein kinase II subunit alpha'
CHEMBL4070
Ki 7.68 7.415 21.0 2
Unchecked
CHEMBL612545
Ki 7.64 7.64 23.0 1
Casein kinase II subunit alpha
CHEMBL3629
Ki 7.37 6.975 43.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22698781 10.1016/j.bmc.2012.05.038 LNCaP 3
19748274 10.1016/j.bmc.2009.08.047 Unchecked 2
22115617 10.1016/j.ejmech.2011.11.002 Casein kinase II subunit alpha 2
22115617 10.1016/j.ejmech.2011.11.002 Casein kinase II subunit alpha' 2
22115617 10.1016/j.ejmech.2011.11.002 Unchecked 1
22698781 10.1016/j.bmc.2012.05.038 Casein kinase II 1

Data from ChEMBL 36 via Core Engine