Assay Detail
Functional
CHEMBL1930615
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human DU145 cells after 3 days by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 5.42 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928921 | — | — | 1 | 5.77 |
| CHEMBL1928923 | — | — | 1 | 5.73 |
| CHEMBL1928924 | — | — | 1 | 5.61 |
| CHEMBL1929082 | — | — | 1 | 5.54 |
| CHEMBL1928925 | — | — | 1 | 5.06 |
| CHEMBL1929083 | — | — | 1 | 4.79 |
| CHEMBL1928926 | — | — | 1 | - |
| CHEMBL1928928 | — | — | 1 | - |
| CHEMBL1926708 | — | — | 1 | - |
| CHEMBL1928929 | — | — | 1 | - |
| CHEMBL1929084 | — | — | 1 | - |
| CHEMBL1929085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928921 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1928923 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL1928924 | — | EC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL1929082 | — | EC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL1928925 | — | EC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL1929083 | — | EC50 | = | 16320.0 | nM | 4.79 |
| CHEMBL1928926 | — | EC50 | - | — | - | |
| CHEMBL1928928 | — | EC50 | - | — | - | |
| CHEMBL1926708 | — | EC50 | - | — | - | |
| CHEMBL1928929 | — | EC50 | - | — | - | |
| CHEMBL1929084 | — | EC50 | - | — | - | |
| CHEMBL1929085 | — | EC50 | - | — | - |