Assay Detail
Binding
CHEMBL1930675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat liver membrane after 1.5 hrs by scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.03 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927702 | — | — | 1 | 7.06 |
| CHEMBL1927695 | — | — | 1 | 5.10 |
| CHEMBL1927694 | — | — | 1 | 4.99 |
| CHEMBL1927697 | — | — | 1 | 4.95 |
| CHEMBL1927700 | — | — | 1 | 4.83 |
| CHEMBL1927698 | — | — | 1 | 4.17 |
| CHEMBL1927696 | — | — | 1 | 4.13 |
| CHEMBL1927699 | — | — | 1 | - |
| CHEMBL1927701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927702 | — | Ki | = | 87.5 | nM | 7.06 |
| CHEMBL1927695 | — | Ki | = | 7870.0 | nM | 5.10 |
| CHEMBL1927694 | — | Ki | = | 10320.0 | nM | 4.99 |
| CHEMBL1927697 | — | Ki | = | 11200.0 | nM | 4.95 |
| CHEMBL1927700 | — | Ki | = | 14690.0 | nM | 4.83 |
| CHEMBL1927698 | — | Ki | = | 67800.0 | nM | 4.17 |
| CHEMBL1927696 | — | Ki | = | 74680.0 | nM | 4.13 |
| CHEMBL1927699 | — | Ki | > | 10000000.0 | nM | - |
| CHEMBL1927701 | — | Ki | = | 1210000.0 | nM | - |