Assay Detail
Functional
CHEMBL1931882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Vaccinia virus Copenhagen infected in HFF cells incubated for 3 days by plaque reduction assay
19
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Vaccinia virus |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927646 | — | — | 1 | 6.30 |
| CHEMBL1927642 | — | — | 2 | 6.00 |
| CHEMBL112159 | — | — | 1 | 6.00 |
| CHEMBL1927643 | — | — | 1 | 5.82 |
| CHEMBL286534 | — | — | 1 | 5.70 |
| CHEMBL1927641 | — | — | 1 | 5.52 |
| CHEMBL1926695 | — | — | 1 | 5.52 |
| CHEMBL1927645 | — | — | 1 | 5.40 |
| CHEMBL1927637 | — | — | 1 | 5.40 |
| CHEMBL1927639 | — | — | 2 | 5.10 |
| CHEMBL1927640 | — | — | 1 | 5.00 |
| CHEMBL1927644 | — | — | 1 | 4.70 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 4.70 |
| CHEMBL1927638 | — | — | 1 | 4.60 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | — | 1 | 4.40 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927646 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL112159 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1927642 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1927643 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL286534 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1927641 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1926695 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1927637 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1927645 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1927642 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1927639 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1927640 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1927644 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5314375 | CIDOFOVIR | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1927638 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1927639 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL392630 | CYCLIC CIDOFOVIR | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL184 | ACYCLOVIR | IC50 | - | — | - | |
| CHEMBL182 | GANCICLOVIR | IC50 | - | — | - |