Assay Detail
Binding
CHEMBL1931908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H][Ile5,6]deltorphin 2 from delta opioid receptor in Wistar rat brain membrane by liquid scintillation counting
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effect of 2',6'-dimethyl-L-tyrosine (Dmt) on pharmacological activity of cyclic endomorphin-2 and morphiceptin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.43 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296603 | DELTORPHINE II | — | 1 | 10.10 |
| CHEMBL1927275 | — | — | 1 | 7.23 |
| CHEMBL1927273 | — | — | 1 | 6.88 |
| CHEMBL1927270 | — | — | 1 | 6.55 |
| CHEMBL1927271 | — | — | 1 | 6.40 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | - |
| CHEMBL362991 | MORPHICEPTIN | — | 1 | - |
| CHEMBL1927272 | — | — | 1 | - |
| CHEMBL1927274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296603 | DELTORPHINE II | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL1927275 | — | IC50 | = | 58.3 | nM | 7.23 |
| CHEMBL1927273 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1927270 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL1927271 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | > | 1000.0 | nM | - |
| CHEMBL362991 | MORPHICEPTIN | IC50 | > | 1000.0 | nM | - |
| CHEMBL1927272 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1927274 | — | IC50 | > | 1000.0 | nM | - |