Assay Detail
Binding
CHEMBL1931964
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Inhibition of hypoxia-induced HIF-1 transcriptional activity by luciferase reporter assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and insight into the structure-activity relationship of 1,3-disubstituted indazoles as novel HIF-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.43 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1928022 | — | — | 1 | 6.13 |
| CHEMBL122024 | — | — | 1 | 6.05 |
| CHEMBL1928023 | — | — | 1 | 6.05 |
| CHEMBL333985 | — | — | 1 | 5.92 |
| CHEMBL1928019 | — | — | 1 | 5.89 |
| CHEMBL1928031 | — | — | 1 | 5.72 |
| CHEMBL1928032 | — | — | 1 | 5.70 |
| CHEMBL1928021 | — | — | 1 | 5.64 |
| CHEMBL334154 | — | — | 1 | 5.30 |
| CHEMBL1928029 | — | — | 1 | 5.11 |
| CHEMBL1928030 | — | — | 1 | 5.07 |
| CHEMBL1928018 | — | — | 1 | 5.05 |
| CHEMBL1928028 | — | — | 1 | 4.92 |
| CHEMBL1928027 | — | — | 1 | 4.87 |
| CHEMBL1928020 | — | — | 1 | 4.77 |
| CHEMBL1928010 | — | — | 1 | 4.62 |
| CHEMBL1928017 | — | — | 1 | - |
| CHEMBL1928016 | — | — | 1 | - |
| CHEMBL1928024 | — | — | 1 | - |
| CHEMBL1928025 | — | — | 1 | - |
| CHEMBL1928026 | — | — | 1 | - |
| CHEMBL1928015 | — | — | 1 | - |
| CHEMBL1928014 | — | — | 1 | - |
| CHEMBL1928013 | — | — | 1 | - |
| CHEMBL1928012 | — | — | 1 | - |
| CHEMBL1928011 | — | — | 1 | - |
| CHEMBL1928009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1928022 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL122024 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1928023 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL333985 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1928019 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1928031 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1928032 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1928021 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL334154 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1928029 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1928030 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1928018 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1928028 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL1928027 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL1928020 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL1928010 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL1928017 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928016 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928024 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928025 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928026 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928015 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928014 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928013 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928012 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928011 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1928009 | — | IC50 | > | 30000.0 | nM | - |