Assay Detail
Binding
CHEMBL1932234
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/Brevig Mission/1/1918(H1N1)) recombinant soluble neuraminidase using 2'-4(methylumbelliferyl)-alpha-D-N-acetylneuraminic acid substrate by fluorimetric assay
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/Brevig Mission/1/1918(H1N1)) |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL1795169) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza Avirus (strain A/South Carolina/1/1918 H1N1)) |
Publication
The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.11 | 8.47 |
| Ki | 2 | 8.60 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | 4.0 | 2 | 9.08 |
| CHEMBL1928608 | — | — | 2 | 8.12 |
| CHEMBL1928610 | — | — | 1 | - |
| CHEMBL1928609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139367 | PERAMIVIR ANHYDROUS | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL139367 | PERAMIVIR ANHYDROUS | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL1928608 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL1928608 | — | IC50 | = | 17.7 | nM | 7.75 |
| CHEMBL1928610 | — | IC50 | = | 37000000.0 | nM | - |
| CHEMBL1928609 | — | IC50 | = | 4000000.0 | nM | - |